1. The Mannich reaction is also considered a condensation reaction. 2. Mannich reaction with dimethylamine and formaldehyde was described.3. Overman has also worked extensively on the aza-Cope-Mannich reaction , originally designed 4. A related reaction is the Mannich reaction . 5. Like the Mannich reaction , aldehydes give good yields while ketones tend to give lower conversion. 6. This is suitable for cleaving glycols and alpha-hydroxy ketones in ring opening and Mannich reaction . 7. In the Mannich reaction , primary or secondary amines or ammonia, are employed for the activation of formaldehyde. 8. Gramine, a useful synthetic intermediate, is produced via a Mannich reaction of indole with dimethylamine and formaldehyde. 9. Additional reactions include aldol reactions, Mannich reaction , Michael reaction, amination, ?-oxyamination, and ?-halogenation. 10. The Mannich reaction is an example of nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base.
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